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Tuesday, September 21, 2021

RUDN University Doctors Study the Harm to the Brain Induced by Manganese - Phys.Org

Last updated Tuesday, September 7, 2021 10:16 ET , Source: NewsService

Manganese poisoning disrupts brain function and can cause Parkinson's disease, amyotrophic lateral sclerosis and other diseases. A constant Mn overexposure in children can cause developmental delays, behavioral deviations. RUDN University doctors, experts in elementology, summarized the data on the harmful effect of manganese on the nervous system and justified the need for experimental studies in vivo. The results are published in the International Journal of Molecular Sciences.

Manganese regulates the development of the nervous system, helps to control the metabolism within the cell, redox reactions, urea transformations. Usually, a person receives enough manganese with food, so a deficiency of this element is rare. At the same time, an overexposure can cause serious poisoning—the brain function is disrupted and the risk of neurodegenerative diseases, including Parkinson's disease and amyotrophic lateral sclerosis, increases. RUDN University doctors have summarized the data that will help save people from manganese poisoning.

"Understanding of the immediate mechanisms of Mn-induced neurotoxicity is rapidly evolving. We seek to provide a summary of recent findings in the field, with an emphasis to clarify existing gaps and future research directions. Мы изучили работы, связанные с исследованиями нейротоксичности марганца за последние пять лет", said Aksana Mazilina, Ph.D., associate professor at the Department of Medical Elementology of RUDN University.

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