This article was originally published here
J Colloid Interface Sci. 2021 Sep 8;607(Pt 2):1382-1390. doi: 10.1016/j.jcis.2021.09.016. Online ahead of print.
ABSTRACT
Metal organic frameworks (MOFs) with physicochemical properties and adjustable structures have been proposed as very attractive materials. The studies on development of such functional materials tended to fabricate featured MOF objects with fascinating catalytic capabilities to utilize their biomedical values. In this paper, we present novel biocompatible manganese metal organic framework (Mn-MOF)-based catalase mimetics with microfluidic microcapsule encapsulation for intravital inflammatory bowel disease (IBD) treatment. Phosphoserine, a component of the cell membrane, served as an organic ligand to ensure biocompatibility of Mn-MOF. Owing to the core-shell structure of the microcapsule, the Mn-MOF exhibited a well-organized distribution and controlled release features, which could protect them from gastric juice and provide function in the intestine. Upon reaching the sites of the inflammatory bowel, Mn-MOF could effectively scavenge reactive oxygen species (ROS) over-produced by neutrophils and macrophages under various gastrointestinal pH environments, protecting intestinal epithelial cells from ROS damage. The Mn-MOF-encapsulated microcapsules exhibited high performances in treating spontaneous IBD in interleukin-10-deficient mice by relieving the oxidative stress, reducing the inflammation, and restoring...
Read Full Story: https://www.docwirenews.com/abstracts/rheumatology-abstracts/microfluidic-encapsulated-manganese-organic-frameworks-as-enzyme-mimetics-for-inflammatory-bowel-disease-treatment/
Your content is great. However, if any of the content contained herein violates any rights of yours, including those of copyright, please contact us immediately by e-mail at media[@]kissrpr.com.
