Compared with comorbidity-matched volunteers, patients recovering from severe COVID-19 did not show evidence of left ventricular dysfunction or a major excess in persistent myocardial injury, researchers reported.
The findings indicated that a high prevalence of CV comorbidities may explain much of the reported myocardial abnormalities on cardiac MRI.
“However, some patients recovering from COVID-19 did have evidence of mild persistent right ventricular dysfunction,” Trisha Singh, BM, clinical research fellow at the University of Edinburgh, Scotland, and colleagues wrote.
In the prospective, two-center observational study, Singh and colleagues sought to better understand the contribution of comorbidities on the reported widespread myocardial abnormalities in patients with recent COVID-19.
The study included patients hospitalized with confirmed COVID-19 who received gadolinium and manganese-enhanced MRI and coronary CTA. After masked analysis, researchers compared these patients with healthy and comorbidity-matched volunteers.
According to results, of the 52 patients (median age, 54 years; 25% women) who recovered from COVID-19, 29% were admitted to intensive care and 21% were ventilated. Additionally, among the 23 patients undergoing coronary CTA, 35% had underlying CAD.
Results revealed that compared with younger healthy volunteers (n = 10), patients with COVID-19 demonstrated reductions in LV ejection fraction (57.4% vs. 66.3%; P = .02) and right ventricular EF (51.7%...
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