- Haein Kim,
- Sunghee Park,
- Hyeonji Seo,
- Hyemin Chung,
- Eun Sil Kim,
- Heungsup Sung,
- Mi-Na Kim,
- Seongman Bae,
- Jiwon Jung,
- Min Jae Kim,
- Sung-Han Kim,
- Sang-Oh Lee,
- Sang-Ho Choi,
- Yang Soo Kim &
- Yong Pil Chong
Abstract
Concern about resistance to chlorhexidine has increased due to the wide use of the latter. The impact of the qacA/B and smr chlorhexidine tolerance genes on the outcome of methicillin-resistant Staphylococcus aureus (MRSA) infections is unclear. We evaluated the prevalence and clinical impact of, and microbiological risk factors for, qacA/B tolerance in MRSA bacteremia. MRSA bacteremia that occurred more than two days after intensive care unit admission between January 2009 and December 2018 was identified from a prospective cohort of S. aureus bacteremia in a tertiary-care hospital from South Korea. A total of 183 MRSA blood isolates was identified, and the major genotype found was ST5-MRSA-II (87.4%). The prevalences of qacA/B and smr were 67.2% and 3.8%, respectively. qacA/B-positive isolates were predominantly ST5-MRSA-II (96.7% [119/123]), the dominant hospital clone. In a homogenous ST5-MRSA-II background, qacA/B positivity was independently associated with septic shock (aOR, 4.85), gentamicin resistance (aOR, 74.43), and non-t002 spa type (aOR, 74.12). qacA/B positivity was found to have decreased significantly in ST5-MRSA-II in association with a decline in qacA/B-positive t2460, despite the increasing use of chlorhexidine...
Read Full Story: https://www.nature.com/articles/s41598-022-15546-3
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